Journal
FREE RADICAL RESEARCH
Volume 43, Issue 6, Pages 523-U5Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/10715760902918683
Keywords
NADPH oxidase (NOX); reactive oxygen species (ROS); human cancer; human tumour cell lines; hydrogen peroxide
Categories
Funding
- National Cancer Institute
- National Institutes of Health [CA33572]
- NATIONAL CANCER INSTITUTE [P30CA033572, ZIABC010677] Funding Source: NIH RePORTER
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The family of NADPH oxidase (NOX) genes produces reactive oxygen species (ROS) pivotal for both cell signalling and host defense. To investigate whether NOX and NOX accessory gene expression might be a factor common to specific human tumour types, this study measured the expression levels of NOX genes 1-5, dual oxidase 1 and 2, as well as those of NOX accessory genes NoxO1, NoxA1, p47(phox), p67(phox) and p22(phox) in human cancer cell lines and in tumour and adjacent normal tissue pairs by quantitative, real-time RT-PCR. The results demonstrate tumour-specific patterns of NOX gene expression that will inform further studies of the role of NOX activity in tumour cell invasion, growth factor response and proliferative potential.
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