Journal
FREE RADICAL RESEARCH
Volume 43, Issue 6, Pages 622-628Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/10715760902942816
Keywords
Tomato; lycopene; isoprostanes; HETEs; 8OHdG; oxidative stress
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Funding
- Biomedical Research Council [03/1/21/18/213]
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This study investigated the effect of a single dose of tomato sauce on healthy male volunteers in a randomized crossover study. Healthy male subjects (n = 10) were enrolled. Placebo (rice and olive oil) or tomato (tomato sauce, rice and olive oil) meals were provided to the volunteers. Blood and urine samples were taken before consumption of meal (0 h) and 2, 4, 6, 24 and 48 h after meal. Consumption of tomato sauce increased plasma lycopene level by 5-22%, with a maximum level at 24 h (pB < 0.01) after the meal. Levels of plasma F-2-isoprostanes, hydroxyeicosatetraenoic acid products, allantoin and urinary 8-hydroxy-2'-deoxyguanosine did not change after either meal, but urinary F-2-isoprostanes (pB < 0.05) significantly decreased at 48 h compared to 0 h after the tomato sauce meal. This study showed that a single dose of tomato sauce meal had only a limited antioxidant effect in vivo.
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