Journal
FREE RADICAL RESEARCH
Volume 43, Issue 3, Pages 224-233Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/10715760802677348
Keywords
Methylmercury; apoptosis; oxidative stress; pyrroloquinoline quinone; neuroprotection; antioxidant
Categories
Funding
- National Outstanding Youth Foundation of China [30125034]
- National Natural Science Foundation of China [30371053]
- scientific and Technological Plan Project of Dalian city [2003B3NS024]
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Pyrroloquinoline quinone (PQQ) is a novel redox cofactor and also exists in various foods. In vivo as well as in vitro experimental studies have shown that PQQ functions as an essential nutrient or antioxidant. Methylmercury (MeHg), as a highly toxic environmental pollutant, could elicit central nervous system (CNS) damage. Considering the antioxidant properties of PQQ, this study was aimed to evaluate the effect of PQQ on MeHg-induced neurotoxicity in the PC12 cells. The results showed that, after pre-treatment of PC12 cells with PQQ prior to MeHg exposure, the MeHg-induced cytotoxicity was significantly attenuated and then the percentage of apoptotic cells and the arrest of S-phase in cell cycle were correspondingly reduced. Moreover, PQQ significantly decreased the production of ROS, suppressed the lipid peroxidation and increased the antioxidant enzyme activities in PC12 cells exposed to MeHg. These observations highlighted the potential of PQQ in offering protection against MeHg-induced neuronal toxicity.
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