Journal
FREE RADICAL RESEARCH
Volume 43, Issue 1, Pages 85-91Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/10715760802610851
Keywords
Isoprostanes; oxidative stress; variation; population; age; gender; demography; humans
Categories
Funding
- Geriatrics Research Foundation
Ask authors/readers for more resources
Oxidative stress is assumed to be the key underlying factor in the pathogenesis of many common diseases. This study describes the basal levels of 8-iso-PGF2 , a major F2-isoprostane and an in vivo oxidative stress biomarker in healthy subjects from three countries, namely Italy, Poland and Sweden, in relation to their smoking habits, age and gender. It studied urinary 8-iso-PGF2 in 588 subjects from Sweden (n=220), Italy (n=203) and Poland (n=165). Polish subjects had the highest levels of F2-isoprostanes followed by the Swedish and Italians when adjusted for smoking, age, sex and creatinine and the inter-country differences were statistically significant. Smokers had significantly higher levels of 8-iso-PGF2 compared to non-smokers in all countries and there was a moderate decrease with age. Women had only slightly lower 8-iso-PGF2 than men. There is a difference in F2-isoprostane levels in vivo between countries. Smoking, age and gender affect isoprostane formation and should be taken into consideration in clinical studies of oxidative stress.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available