Journal
FREE RADICAL BIOLOGY AND MEDICINE
Volume 133, Issue -, Pages 130-143Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.freeradbiomed.2018.09.043
Keywords
Ferroptosis; Iron; Cysteine; Lipid peroxidation; Cell death; Metabolism; Chemical biology
Funding
- National Institutes of Health/National Cancer Institute [1R35CA209896, P01CA087497]
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The term ferroptosis was coined in 2012 to describe an iron-dependent regulated form of cell death caused by the accumulation of lipid-based reactive oxygen species; this type of cell death was found to have molecular characteristics distinct from other forms of regulated cell death. Features of ferroptosis have been observed periodically over the last several decades, but these molecular features were not recognized as evidence of a distinct form of cell death until recently. Here, we describe the history of observations consistent with the current definition of ferroptosis, as well as the advances that contributed to the emergence of the concept of ferroptosis. We also discuss recent implications and applications of manipulations of the ferroptotic death pathway.
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