Journal
FREE RADICAL BIOLOGY AND MEDICINE
Volume 62, Issue -, Pages 111-120Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.freeradbiomed.2013.01.003
Keywords
Parkinson disease; Oxidative damage; Macromolecules; Rotenone; Free radicals
Funding
- NIEHS (NIH)
- NINDS (NIH)
- American Parkinson Disease Association Center for Advanced Research at the University of Pittsburgh
Ask authors/readers for more resources
Parkinson disease (PD), the most common neurodegenerative movement disorder, is associated with selective degeneration of nigrostriatal dopamine neurons. Although the underlying mechanisms contributing to neurodegeneration in PD seem to be multifactorial, mitochondrial impairment and oxidative stress are widely considered to be central to many forms of the disease. Whether oxidative stress is a cause or a consequence of dopaminergic death, there is substantial evidence for oxidative stress both in human PD patients and in animal models of PD, especially using rotenone, a complex I inhibitor. There are many indices of oxidative stress, but this review covers the recent evidence for oxidative damage to nucleic acids, lipids, and proteins in both the brain and the peripheral tissues in human PD and in the rotenone model. Limitations of the existing literature and future perspectives are discussed. Understanding how each particular macromolecule is damaged by oxidative stress and the interplay of secondary damage to other biomolecules may help us design better targets for the treatment of PD. (C) 2013 Elsevier Inc. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available