Journal
FREE RADICAL BIOLOGY AND MEDICINE
Volume 64, Issue -, Pages 95-105Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.freeradbiomed.2013.07.004
Keywords
MicroRNA; MyomiR; Skeletal muscle; Exercise; Free radicals
Funding
- NIAMS NIH HHS [R01 AR061939] Funding Source: Medline
- NIA NIH HHS [R01 AG049806] Funding Source: Medline
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MicroRNAs (miRNAs) have emerged as important players in the regulation of gene expression, being involved in most biological processes examined to date. The proposal that miRNAs are primarily involved in the stress response of the cell makes miRNAs ideally suited to mediate the response of skeletal muscle to changes in contractile activity. Although the field is still in its infancy, the studies presented in this review highlight the promise that miRNAs will have an important role in mediating the response and adaptation of skeletal muscle to various modes of exercise. The roles of miRNAs in satellite cell biology, muscle regeneration, and various myopathies are also discussed. (C) 2013 Elsevier Inc. All rights reserved.
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