Journal
FREE RADICAL BIOLOGY AND MEDICINE
Volume 52, Issue 6, Pages 973-982Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.freeradbiomed.2011.11.038
Keywords
Fatty acid; Redox regulation; Nrf2; Keap1; Heat shock response; Unfolded protein response; Electrophilic stress response; HNE; Oxidized phospholipids; Nitroalkenes
Funding
- Academy of Finland
- Sigrid Juselius Foundation
- Finnish Cultural Foundation
- Finnish Foundation for Cardiovascular Research
- Finnish Medical Foundation
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Unsaturated fatty acids are prone to radical reactions that occur in biological situations where extensive formation of reactive oxygen and nitrogen species (ROS and RNS) takes place. These reactions are frequent in inflammatory conditions such as atherosclerosis, and yield a variety of biologically active species, many of which are electrophilic in nature. Electrophilic lipid oxidation and nitration products can influence redox cell signaling via S-alkylation of protein thiols, and moderate exposure to these species evokes protective cell signaling responses through this mechanism. Herein, we review the stress signaling pathways elicited by electrophiles derived from unsaturated fatty acids, focusing on the Keap1-Nrf2 pathway, the heat shock response pathway (HSR), and the unfolded protein response pathway (UPR). (C) 2011 Elsevier Inc. All rights reserved.
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