Journal
FREE RADICAL BIOLOGY AND MEDICINE
Volume 51, Issue 2, Pages 314-326Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.freeradbiomed.2011.04.031
Keywords
ROS; Sulfenic acid; Cysteine protection; Sulfenylated cysteines
Funding
- FWO
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Protein sulfenic acid formation has long been regarded as unwanted damage caused by reactive oxygen species (ROS). However, over the past 10 years, accumulating evidence has shown that the reversible oxidation of cysteine thiol groups to sulfenic acid functions as a redox-based signal transduction mechanism. Here, we review the mechanisms of sulfenic acid formation by ROS. We present some of the most important roles played by sulfenic acids in living cells as well as the pathways that regulate sulfenic acid formation. We highlight the experimental tools that have been developed to study the cellular sulfenome and show how computational approaches might help to better understand the mechanisms of sulfenic acid formation. (C) 2011 Elsevier Inc. All rights reserved.
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