Journal
FREE RADICAL BIOLOGY AND MEDICINE
Volume 50, Issue 10, Pages 1274-1279Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.freeradbiomed.2011.02.008
Keywords
Nitroxyl (HNO); Nitric oxide (NO); Membrane inlet mass spectrometry; Angeli's salt; Piloty's acid; 2-bromo-Piloty's acid; Free radicals
Funding
- Division Of Chemistry
- Direct For Mathematical & Physical Scien [0911305] Funding Source: National Science Foundation
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Membrane inlet (or introduction) mass spectrometry (MIMS) was used to detect nitroxyl (HNO) in aqueous solution for the first time. The common HNO donors Angeli's salt (AS) and Piloty's acid (PA), along with a newly developed donor, 2-bromo-N-hydroxybenzenesulfonamide (2-bromo-Piloty's acid, 2BrPA), were examined by this technique. MIMS experiments revealed that under physiological conditions 2BrPA is an essentially pure HNO donor, but AS produces a small amount of nitric oxide (NO). In addition, MIMS experiments also confirmed that PA is susceptible to oxidation and NO production, but that 2BrPA is not as prone to oxidation. (C) 2011 Elsevier Inc. All rights reserved.
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