Journal
FREE RADICAL BIOLOGY AND MEDICINE
Volume 49, Issue 1, Pages 31-39Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.freeradbiomed.2010.03.011
Keywords
Parkinson's disease; Oxidative stress, primary mesencephalic; Neuron cultures; Newborn mice; PSI-Parkinson model
Funding
- Murst-Italia
- Fondazione Cassa di Risparmio di Perugia, Italia [2006.0216.020]
Ask authors/readers for more resources
Initiation and progression of Parkinson's disease seem to be linked to oxidative stress, closely related to decreased mitochondrial functions and ubiquitin proteasome system dysfunction. To date, L-Dopa is the most effective medication, although long-term treatment can enhance oxidative stress and accelerate the degenerative process of residual cells. Therefore the inhibition of oxidation of L-Dopa/dopamine and the inhibition of reactive oxygen species formation are important strategies for neuroprotective therapy. Recently, several dual acting drugs, in which L-Dopa/dopamine are covalently linked to antioxidant molecules, were shown to induce sustained delivery of both L-Dopa/dopamine in rat plasma and striatum, suggesting that these compounds might be proposed as useful agents against Parkinson's disease. Here, by analyzing GSH levels and heme oxygenase-1 expression, we investigated in primary mesencephalic neuron cultures and in newborn mice the effects of the treatment with Ac-Met-LD-OMe. Moreover, by using proteasome inhibitor-treated mice as Parkinson's disease animal model, we demonstrated the beneficial effects of the systemic administration of this novel codrug. (C) 2010 Elsevier Inc. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available