Journal
FREE RADICAL BIOLOGY AND MEDICINE
Volume 49, Issue 12, Pages 2028-2031Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.freeradbiomed.2010.09.029
Keywords
Aging; Antioxidant; Catalase; Superoxide dismutase; Life span; Free radicals
Funding
- National Institute on Aging National Institutes of Health [RO1 AG7657]
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The simultaneous overexpression of multiple copies of Mn superoxide dismutase (SOD) and ectopic catalase (mtCat) transgenes in the mitochondria of the fruit fly Drosophila melanogaster was shown previously to diminish the life span The hypothesis tested in this study was that this effect was due primarily to the presence of one or the other transgene An alternative hypothesis was that both transgenes have additive negative effects Crosses were performed between five pairs of transgenic lines containing single-copy insertions of mtCat Mn SOD or P element vector control transgenes at unique loci and the life spans of progeny containing two mtCat Mn SOD or vector insertions were determined Increasing amounts of mitochondrial catalase activity tended to be associated with decreases in mean life span Overexpression of two copies of the genomic Mn SOD transgene had no effect on life span The results do not support the hypothesis that enhanced mitochondrial SOD or catalase activity promotes longevity in flies (C) 2010 Elsevier Inc All rights reserved
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