Journal
FREE RADICAL BIOLOGY AND MEDICINE
Volume 46, Issue 5, Pages 573-578Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.freeradbiomed.2008.11.005
Keywords
White wine; Red wine; Resveratrol; Tyrosol; Hydroxytyrosol; PBEF; SirT1; FoxO1; Longevity; Cardioprotection
Funding
- NIH [HL 22559, HL33889, HL34360]
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Resveratrol increases longevity through SirT1, which is activated with NAD(+) supplied by an anti-aging enzyme PEER SirT1 interacts with an anti-aging transcription factor, FoxO1, which is negatively regulated by Akt. Since white wine could have similar health benefits as red wine, we determined if white wine and its cardioprotective components possess anti-aging properties by feeding rats with these compounds. The hearts expressed SirT, FoxO, and PBEF in the order of white wine>resveratrol>tyrosol>hydroxytyrosol>red wine, while cardioprotection shown by reduction of infarct size and cardiomyocyte apoptosis followed a different pattern: resveratrol>red wine>hydroxytyrosol>white wine>tyrosol, suggesting the existence of different signaling mechanisms for the induction of longevity and survival. Published by Elsevier Inc.
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