Journal
FREE RADICAL BIOLOGY AND MEDICINE
Volume 46, Issue 2, Pages 127-137Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.freeradbiomed.2008.10.024
Keywords
Oxidized LDL; Transcription factors; Gene expression; Oxidative stress; Free radicals
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It is well recognized that oxidized LDL (OxLDL.) plays a crucial role in the initiation and progression of atherosclerosis. Many biological effects of OxLDL are mediated through signaling pathways, especially via the activation of transcription factors, which in turn Stimulate the expression of genes involved in the inflammatory and oxidative stress response or in cell cycle regulation. In this review, we will discuss the various transcription factors activated by OxLDL, the Studied Cell types, the active Compounds of the OxLDL. particle, and the downstream genes when identified. Identification of the transcription factors and some of the downstream genes regulated by OxLDL has helped LIS understand the Molecular mechanism involved in generation of the atherosclerotic plaque. (C) 2008 Elsevier Inc. All rights reserved.
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