Journal
FREE RADICAL BIOLOGY AND MEDICINE
Volume 46, Issue 12, Pages 1562-1566Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.freeradbiomed.2008.12.023
Keywords
Resveratrol; Wine; Biomarkers; Free radicals
Funding
- Spanish Ministry of Science and Innovation [CSD2007-063, AGL2006-14228-C03-02/01, 2005-0559]
- ISCIII
- Departament d'Universitats
- Recerca i Societat de la Informacio
- Generalitat de Catalunya
- Spanish Ministry of Science and innovation
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Several clinical and epidemiological studies have shown that moderate wine consumption may exert a protective effect against oxidative stress involved in several diseases, such as cardiovascular and neurodegenerative disorders. However, the epidemiological assessment of wine consumption has usually been obtained using self-reported questionnaires containing less reliable information for assessing total intake than nutritional biomarkers. A reliable biomarker for wine consumption is, therefore, needed. To validate urinary resveratrol metabolites (RMs) as a biomarker of wine consumption in a large cohort of free-living subjects, 1000 consecutive subjects entering a substudy of the PREDIMED trial (Prevencion con Dieta Mediterranea) were evaluated. Data were collected in a validated semi quantitative food frequency questionnaire. RMs were measured in morning urine by LC-MS/MS. Urinary RM values correlated directly with reported daily amounts of wine consumed (r = 0.895; p < 0.001). One drink of wine per week can be detected. Using a cut-off of 411.4 nmol/g creatinine, the measurement Of urinary RMs Could discriminate wine consumers from non-wine consumers with a sensitivity of 93.3% (95% confidence interval (CI) 91.5-94.7%) and a specificity of 92.1% (CI 90.2-93.7%). Urinary RMs fulfill the criteria to be considered as a nutritional biomarker of wine consumption in a large sample of free-living subjects. This biomarker would provide an additional tool for investigating more precisely the relationship between wine consumption and health benefits. (c) 2009 Elsevier Inc. All rights reserved.
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