Journal
FREE RADICAL BIOLOGY AND MEDICINE
Volume 44, Issue 10, Pages 1817-1832Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.freeradbiomed.2008.02.001
Keywords
cellular senescence; oxidative stress; ethanol; DNA arrays; human fibroblasts; TGF-beta 1; IGFBP-3
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Repeated exposures to sublethal concentrations of tert-butylhydroperoxide and ethanol trigger premature senescence of WI-38 human diploid fibroblasts. We found 16 replicative senescence-related genes with similar alterations in expression level in replicative senescence and two models of stress-induced premature senescence. Among these genes was IGFBP-3. Using a siRNA approach, we showed that IGFBP-3 regulates the appearance of several biomarkers of senescence after repeated exposures of WI-38 fibroblasts to tert-butylhydroperoxide and ethanol. (C) 2008 Elsevier Inc. All rights reserved.
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