Journal
FREE RADICAL BIOLOGY AND MEDICINE
Volume 44, Issue 12, Pages 2051-2057Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.freeradbiomed.2008.03.012
Keywords
Alzheimer disease; 3xTg-AD mouse; oxidative stress; lipid peroxidation; antioxidants; free radicals
Ask authors/readers for more resources
Alzheimer disease (AD) is a neurodegenerative disease which is characterized by the presence of extracellular senile plaques mainly composed of amyloid-beta peptide (A beta), intracellular neurofibrillary tangles, and selective synaptic and neuronal loss. AD brains revealed elevated levels of oxidative stress markers which have been implicated in A beta-induced toxicity. In the present work we addressed the hypothesis that oxidative stress occurs early in the development of AD and evaluated the extension of the oxidative stress and the levels of antioxidants in an in vivo model of AD, the triple-transgenic mouse, which develops plaques, tangles, and cognitive impairments and thus mimics AD progression in humans. We have shown that in this model, levels of antioxidants, namely, reduced glutathione and vitamin E, are decreased and the extent of lipid peroxidation is increased. We have also observed increased activity of the antioxidant enzymes glutathione peroxidase and superoxide dismutase. These alterations are evident during the A beta oligomerization period, before the appearance of A beta plaques and neurofibrillary tangles, supporting the view that oxidative stress occurs early in the development of the disease. (C) 2008 Elsevier Inc. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available