Journal
FREE RADICAL BIOLOGY AND MEDICINE
Volume 45, Issue 4, Pages 357-366Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.freeradbiomed.2008.04.010
Keywords
3-nitrotyrosine; protein nitration; peroxynitrite; free radicals; nitric oxide
Funding
- Howard Hughes Medical Institute Funding Source: Medline
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Protein 3-nitrotyrosine is a posttranslational modification found in many pathological conditions from acute to chronic diseases. Could 3-nitrotyrosine formation participate on the basis of these diseases or is it just a marker connected with the associated nitroxidative stress? In vitro and in vivo data, including proteomic research, show that protein tyrosine nitration is a selective process where only a small amount of proteins is found nitrated and one or a few tyrosine residues are modified in each. Accumulating data suggest a strong link between protein 3-nitrotyrosine and the mechanism involved in disease development. In this review, we analyze the factors determining protein 3-nitrotyrosine formation, the functional and biological outcome associated with protein tyrosine nitration, and the fate of the nitrated proteins. (c) 2008 Elsevier Inc. All rights reserved.
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