Synthesis, spectroscopic, thermal analysis and in vitro biological properties of some new metal complexes with gemifloxacin and 1,10-phenanthroline

In this study, mixed ligand complexes derived from gemifloxacin as primary ligand and 1,10-phenanthroline as secondary ligand have been prepared and characterized by conventional techniques including elemental analyses, infrared, electronic spectra, H-1 NMR, mass and thermal analyses. The infrared spectral data show the chelation behavior of the ligands toward the metal ions through oxygen of pyridone, one oxygen of carboxylic group of gemifloxacin and pyridyl nitrogen of 1,10-phenanthroline. Thermal analyses show that the complexes lose water molecules of hydration initially and subsequently expel coordinated water molecules and organic ligands in continuous steps. The calculated bond length and force constant, F(U=O), in the uranyl complex are 1.753 a<< and 636.33 Nm(-1), respectively. Also, the two ligands, in comparison with its metal complexes, are screened for their antimicrobial activity. Activity index data showed that La(III) is the highest activity and shows very highly significant against Bacillus subtilis compared with gemifloxacin. The anticancer activity was screened against breast cancer cell line and colon cancer cell line.