Journal
FORENSIC TOXICOLOGY
Volume 33, Issue 1, Pages 1-11Publisher
SPRINGER
DOI: 10.1007/s11419-014-0242-9
Keywords
2C-B; Nexus; 25B-NBOMe; New Nexus; Substituted phenethylamines; Toxicology and pharmacology
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Substituted phenethylamines are a class of designer drugs that hold a significant position in the drug abuse market. The most important substances within this class appear to be 4-bromo-2,5-dimethoxyphenethylamine (2C-B) and its novel derivative 2-(4-bromo-2,5-dimethoxyphenyl)-N-(2-methoxybenzyl)ethanamine (25B-NBOMe). Intoxications related to 2C-B use are still recorded worldwide, despite the fact that its use and trafficking are banned in many countries. 25B-NBOMe is a highly potent 2C-B derivative that has invaded recently in the drug arena and is considered legal to possess and supply in many countries. This manuscript reviews all available information regarding chemistry, availability, pharmacology, and toxicology of 2C-B and 25B-NBOMe. The intoxication and fatal cases reported, as well as the current legislation of these drugs, are also presented.
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