Journal
FORENSIC TOXICOLOGY
Volume 27, Issue 2, Pages 75-80Publisher
SPRINGER
DOI: 10.1007/s11419-009-0073-2
Keywords
Amphetamine-type stimulants; Chiral analysis; High throughput; GC-MS; Narrow-bore capillary column; Trifluoroacetyl-L-prolyl chloride
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Funding
- Japan Society for the Promotion of Science [18390207, 17590588]
- Grants-in-Aid for Scientific Research [17590588, 18390207] Funding Source: KAKEN
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We report very rapid and simultaneous chiral analysis of urinary amphetamine-type stimulants (ATSs), including amphetamine, methamphetamine, 3,4-methylenedioxyamphetamine, 3,4-methylenedioxymethamphetamine, and 3,4-methylenedioxyethylamphetamine, using gas chromatography-mass spectrometry (GC-MS) with a simple procedure. A urine sample containing ATSs was subjected to extractive derivatization on a diatomaceous earth tube with trifluoroacetyl-l-prolyl chloride in a single step. The concentrated sample was analyzed by GC-MS, using a short narrow-bore capillary column (10 m x 0.1 mm i.d.) in split injection mode. All chiral isomers of the ATSs targeted in this study were chromatographically distinguishable within 5 min. By our method, ATSs in urine could be measured in the concentration range of 20-1000 ng/ml with coefficients of variation of less than 9%. Our method will be very useful for chiral analysis of ATSs in routine forensic toxicology investigations, because of its simplicity and rapidity.
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