Journal
FORENSIC TOXICOLOGY
Volume 27, Issue 2, Pages 61-66Publisher
SPRINGER
DOI: 10.1007/s11419-009-0069-y
Keywords
1-Pentyl-3-(1-naphthoyl)indole; Naphthalen-1-yl-(1-pentylindol-3-yl)methanone; JWH-018; Cannabimimetic indole; Designer drug; Herbal product
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Funding
- Ministry of Health, Labour, and Welfare of Japan
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A cannabimimetic indole has been identified as a new adulterant in a herbal product being sold illegally in Japan for its expected narcotic effect. Liquid chromatography-mass spectrometry and gas chromatography-mass spectrometry analyses indicated that the product contained two major compounds. One was identified as a cannabinoid analog (1RS,3SR)-3-[4-(1,1-dimethyloctyl)-2-hydroxyphenyl]cyclohexan-1-ol (1) by direct comparison with the authentic compound, which we reported previously. The other compound (2) showed a molecular weight of 341 daltons, and accurate mass spectral measurements showed its elemental composition to be C24H23NO. Both mass and nuclear magnetic resonance spectrometric data revealed that 2 was 1-pentyl-3-(1-naphthoyl)indole [or naphthalen-1-yl-(1-pentylindol-3-yl)methanone] being identical to JWH-018, which was synthesized by Wiley and coworkers in 1998. This compound was reported as a potent cannabinoid receptor agonist possessing a pharmacological cannabimimetic activity.
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