Journal
FORENSIC SCIENCE INTERNATIONAL-GENETICS
Volume 10, Issue -, Pages 12-16Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.fsigen.2013.12.009
Keywords
SNPs; Chile; Human identification; Allele frequency databases; Population sub-structure
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Funding
- Xunta de Galicia [INCITE 09 208163PR]
- Deputacion da Coruna
- Fundacion Pedro Barrie de la Maza
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Chile is a disproportionately long and narrow country defined by the southern Andes and Pacific coastline where a level of genetic sub-structure resulting from distances of several thousand kilometers might be expected across the most distantly separated regions. Although STR databases created for the Chilean Legal Medical Service indicate an absence of sub-structure, such a characteristic requires further exploration when introducing additional forensic markers. Notably, Single Nucleotide Polymorphisms (SNPs) have a much lower mutation rate than STRs and can show more stable distributions of genetic variation if population movement is restricted. In this study we evaluated 451 Chilean urban samples from the North, North-Central, Central, South-Central and South regions of Chile for the 52 SNPs of the SNPforID forensic identification panel to explore the underlying genetic structure of Chilean populations. Results reveal similar genetic distances between groups suggesting a single SNP database for the whole of Chile is appropriate. To further understand the genetic composition of Chilean populations that comprise the bulk of individuals with both European and Native American ancestries, ancestral membership proportions were evaluated and pairwise comparisons to other American populations were made. (C) 2014 Elsevier Ireland Ltd. All rights reserved.
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