Journal
FORENSIC SCIENCE INTERNATIONAL-GENETICS
Volume 12, Issue -, Pages 12-23Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.fsigen.2014.04.008
Keywords
Gene diversity; Discriminatory power; AMOVA; Population structure; Database
Categories
Funding
- Ministerio de Ciencia e Innovacion [SAF2011-26983]
- Plan Galego IDT, Xunta de Galicia [EM 2012/045]
- FCT
- FCT [Programa COMPETE, European Union] [PTDC/CS-ANT/108558/2008]
- Collaborative Innovation Center of Judicial Civilization, China University of Political Science and Law
- NRF
- UWC
- Ellen og Aage Andersen's Foundation
- Foundations Pool Professorship (Paulo Foundation)
- Wellcome Trust [098051]
- National Natural Science Foundation of China [31100906, 81241136]
- Leverhulme Trust [F/00 212/AM]
- Wellcome Trust Senior Fellowship in Basic Biomedical Science [087576]
- MINDEF, Singapore
- Department of Science and Technology - Philippine Council for Industry, Energy and Emerging Technology Research and Development (DOST-PCIEERD)
- Office of the Vice President for Academic Affairs, University of the Philippines (UP-OVPAA)
- Office of the Vice Chancellor for Research and Extension, University of the Philippines Los Banos (UPLB-OVCRE)
- FWO Vlaanderen
- CAPES
- CNPq
- University of Buenos Aires [20020100100744 UBACyT]
- CONICET [PIP 112-200801-02836]
- Promega Corporation
- FEDER
- Fundação para a Ciência e a Tecnologia [PTDC/CS-ANT/108558/2008] Funding Source: FCT
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In a worldwide collaborative effort, 19,630 Y-chromosomes were sampled from 129 different populations in 51 countries. These chromosomes were typed for 23 short-tandem repeat (STR) loci (DYS19, DYS389I, DYS389II, DYS390, DYS391, DYS392, DYS393, DYS385ab, DYS437, DYS438, DYS439, DYS448, DYS456, DYS458, DYS635, GATAH4, DYS481, DYS533, DYS549, DYS570, DYS576, and DYS643) and using the PowerPlex Y23 System (PPY23, Promega Corporation, Madison, WI). Locus-specific allelic spectra of these markers were determined and a consistently high level of allelic diversity was observed. A considerable number of null, duplicate and off-ladder alleles were revealed. Standard single-locus and haplotype-based parameters were calculated and compared between subsets of Y-STR markers established for forensic casework. The PPY23 marker set provides substantially stronger discriminatory power than other available kits but at the same time reveals the same general patterns of population structure as other marker sets. A strong correlation was observed between the number of Y-STRs included in a marker set and some of the forensic parameters under study. Interestingly a weak but consistent trend toward smaller genetic distances resulting from larger numbers of markers became apparent. (C) 2014 The Authors. Published by Elsevier Ireland Ltd.
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