Journal
FORENSIC SCIENCE INTERNATIONAL-GENETICS
Volume 5, Issue 2, Pages 78-83Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.fsigen.2011.01.010
Keywords
Haplotype; mtDNA; Y-haplotype; Likelihood ratio; Match probability; Theta correction; Population genetics
Categories
Funding
- NIGMS NIH HHS [R01 GM075091-04, R01 GM075091, GM 075091] Funding Source: Medline
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Mitochondrial DNA (mtDNA) and the non-recombining portion of the Y-chromosome are inherited matrilinealy and patrilinealy, respectively, and without recombination. Collectively they are termed 'lineage markers'. Lineage markers may be used in forensic testing of an item, such as a hair from a crime scene, against a hypothesised source, or in relationship testing. An estimate of the evidential weight of a match is usually provided by a count of the occurrence in some database of the mtDNA or Y-STR haplotype under consideration. When the factual statement of a count in the database is applied to a case, issues of relevance of the database and sampling uncertainty may arise. In this paper, we re-examine the issues of sampling uncertainty, the relevance of the database, and the combination of autosomal and lineage marker evidence. We also review the recent developments by C.H. Brenner. (C) 2010 Elsevier Ireland Ltd. All rights reserved.
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