Journal
JOURNAL OF THEORETICAL BIOLOGY
Volume 376, Issue -, Pages 15-31Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.jtbi.2015.03.021
Keywords
Epithelium; Proliferation; Mitosis; Immigration; Emigration; Branching process
Categories
Funding
- National Institutes of Health [R01 EY09852, R01 EY024607]
- Core Grant for Vision Research [P30EY02687]
- Research to Prevent Blindness
- Marie Curie International Outgoing Fellowship within the 7 th European Community Framework Programme [FP7-PEOPLE-2013-IOF-622890-MoLeGro]
- Croatian Science Foundation [3526]
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The size and shape of the ocular lens must be controlled with precision if light is to be focused sharply on the retina. The lifelong growth of the lens depends on the production of cells in the anterior epithelium. At the lens equator, epithelial cells differentiate into fiber cells, which are added to the surface of the existing fiber cell mass, increasing its volume and area. We developed a stochastic model relating the rates of cell proliferation and death in various regions of the lens epithelium to deposition of fiber cells and radial lens growth. Epithelial population dynamics were modeled as a branching process with emigration and immigration between proliferative zones. Numerical simulations were in agreement with empirical measurements and demonstrated that, operating within the strict confines of lens geometry, a stochastic growth engine can produce the smooth and precise growth necessary for lens function. (C) 2015 Elsevier Ltd. All rights reserved.
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