Journal
FOOD SCIENCE AND BIOTECHNOLOGY
Volume 21, Issue 2, Pages 587-595Publisher
KOREAN SOCIETY FOOD SCIENCE & TECHNOLOGY-KOSFOST
DOI: 10.1007/s10068-012-0075-4
Keywords
Cratoxylum formosum; quercetin; quercetin glycoside; cellular antioxidant capacity; anti-inflammatory activity
Categories
Funding
- Ministry of Education, Science Technology (MEST)
- Korea Institute for Advancement of Technology (KIAT)
Ask authors/readers for more resources
In this study, quercetin, quercetin-3-O-beta-d-glucopyranoside (isoquercitrin), quercetin-3-O-beta-d-galactopyranoside (hyperin), and quercertin-3-O-alpha-l-rhamnoside (quercitrin) from mampat (Cratoxylum formosum) were isolated and their antioxidative and anti-inflammatory activities were investigated. Quercetin displayed weaker antioxidant activity than its glycosides, while the cellular antioxidant capacity of quercetin and hyperin was stronger than that of isoquercitrin and quercitrin, indicating that the higher cell-membrane permeability of quercetin and hyperin than isoquercitrin and quercitrin was due to the different hydrophobicity and the specific membrane receptor for galactose. The anti-inflammatory activity of quercetin was shown to be higher to its glycosides in nitric oxide (NO) production, inducible nitric oxide synthase (iNOS) expression, and nuclear factor (NF)-kappa B activation, suggesting that quercetin inhibits NO production in LPS-stimulated RAW 264.7 cells via control of iNOS expression with attenuation of NF-kappa B activation. The data obtained in this study illustrates that the presence and kind of monosaccharide in quercetin glycosides may play a critical role in their cellular antioxidant and anti-inflammatory activities.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available