Journal
FOOD RESEARCH INTERNATIONAL
Volume 51, Issue 2, Pages 587-595Publisher
ELSEVIER
DOI: 10.1016/j.foodres.2013.01.023
Keywords
Grape seed procyanidin extract; Polyphenols; Procyanidins; Hypertension; Oxidative stress; Spontaneously hypertensive rats
Categories
Funding
- Ministerio de Educacion y Ciencia of the Spanish Government [AGL 2008-00387/ALI]
- Universitat Rovira i Virgili-Banco Santander [2011 LINE-12]
Ask authors/readers for more resources
Grapes are a good source of flavonoids, which have been previously demonstrated to exert beneficial healthy effects on cardiovascular diseases. The aims of this study were to extensively characterise a grape seed procyanidin extract (GSPE) (total phenolic content, antioxidant capacity and HPLC-MS phenolic profile) and, to assess its antihypertensive effect in spontaneously hypertensive rats (SHR) which is a model of genetically hypertensive rat analogue to the essential hypertension in humans. The hypotensive effect of GSPE was also proved in normotensive Wistar-Kyoto rats. Chromatographic analysis of the extract showed that the most abundant polyphenols are monomers and dimers, in their free forms and linked to a gallate. GSPE produced a significant decrease in systolic and diastolic blood pressure of SHR dose-dependently up to 375 mg/kg (maximum decrease 6 h post-administration) and did not affect blood pressure of Wistar-Kyoto rats. GSPE increased the activity of an antioxidant endogen system, but did not affect plasma ACE activity in these animals. (C) 2013 Elsevier Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available