4.7 Article

Physicochemical properties and regulatory effects on db/db diabetic mice of β-glucans extracted from oat, wheat and barley

Journal

FOOD HYDROCOLLOIDS
Volume 37, Issue -, Pages 60-68

Publisher

ELSEVIER SCI LTD
DOI: 10.1016/j.foodhyd.2013.10.007

Keywords

Oat beta-glucan; Wheat beta-glucan; Barley beta-glucan; Rheological characteristics; db/db diabetic mice

Funding

  1. Chinese Agricultural Research System [CARS-08-D]
  2. Chinese Ministry of Agriculture
  3. International Cooperation Program of Shaanxi and Technology RD Plan [2011KW-28]
  4. International Platform Project, Northwest AF University

Ask authors/readers for more resources

Physicochemical properties of different beta-glucan purified from oat, barley and wheat, were investigated by measuring the composition, molecular weight, intrinsic viscosity ([eta]), and rheological properties. The main objective was to investigate the relationship between effects of regulation of cholesterol metabolism and antioxidant property on db/db diabetic mice of beta-glucans and their molecular weights and viscosities. Metformin was used as the positive control. The levels of blood glucose, serum lipid, liver lipid, superoxide dismutase (SOD) and malondialdehyde (MDA) in liver were determined. Results showed that average values of molecular weight (MW) of beta-glucan from oat, wheat and barley were 172 kDa, 635 kDa and 743 kDa; the viscosities of beta-glucans were positively correlated with their corresponded molecular weights, and wheat and barley beta-glucan showed significant shear thinning ability compared to oat beta-glucan; Barley beta-glucans had higher G' compared to wheat and oat, and the latter had higher G ''. Blood glucose differences were not significant due to high variability, however serum TC, TG, liver TC, TG and LDL-C were lower in beta-glucan fed groups compared to control. Moreover, the HDL-C was higher in beta-glucan fed groups compared to control group. The addition of beta-glucan fed to the db/db diabetic mice significantly (P < 0.05) increased their liver SOD activities and reduced their MDA levels (P > 0.05). A correlation between the measured biological parameters and the molecular weight or viscosity of beta-glucan was observed. Lack of beta-glucanase degeneration was the main cause of the low MW beta-glucan and its diminished physiological effect. Crown Copyright (C) 2013 Published by Elsevier Ltd. All rights reserved.

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.7
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

No Data Available
No Data Available