Journal
FOOD HYDROCOLLOIDS
Volume 32, Issue 1, Pages 72-78Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.foodhyd.2012.11.006
Keywords
Nanostructured lipid carriers; alpha-Lipoic acid; Emulsifying agent; High pressure homogenization; Food solution
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Funding
- Chinese National Natural Science Foundation [201003047]
- Fundamental Research Funds for the Central Universities [WK1014024]
- International Cooperation Project of the Ministry of Science and Technology of PRC [2008DFB50060]
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alpha-Lipoic acid loaded nanostructured lipid carriers (ALA-NLC) were developed by high pressure homogenization (HPH) technology. The effects of polymer-surfactant emulsifying agents on the formation and stability of ALA-NLC were characterized by dynamic light scattering (DLS), rheological analysis, wide angle X-ray diffraction (WAXD), and high efficiency liquid chromatography (HPLC). The particles size, viscoelastic property and stability of ALA-NLC samples were significantly influenced by polymer -surfactant emulsifying agents. Polymer is considered as a primary emulsifying agent in ALA-NLC. Surfactants, which have small and flexible hydrophilic head group, would have strong interaction with polymer, and form strong interfacial film, thus could improve the stability of ALA-NLC. These results will be productive for better understanding of the preparation and stability of NLC, and two formulations applied here may have some potential applications for alpha-lipoic acid dietary supplement or nutri-cosmetics. (c) 2012 Elsevier Ltd. All rights reserved.
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