Novel one-pot process for the synthesis Of ethyl 2-imino-4-methyl-2,3-dihydrothiazole-5-carboxylates

A facile one-pot, two-step process for the synthesis of ethyl 2-imino-4-methyl-2,3-dihydrothiazole-5-carboxylates via the cyclocondensation of ethyl 3-oxo-2-thiocyanatobutanoate with a variety of hydrazine and hydrazide derivatives was developed. Ethyl 3-oxo-2-thiocyanatobutanoate itself was synthesized as an intermediate from the reaction of ethyl 2-chloroacetoacetate with potassium thiocyanate (KSCN). The molecular structures of these newly synthesized compounds were elucidated based on elemental analysis and spectral data.