Journal
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
Volume 96, Issue 4, Pages 1093-1100Publisher
WILEY
DOI: 10.1002/jsfa.7181
Keywords
natural antioxidants; anthocyanins; berries; porcine intestinal epithelial cells
Funding
- VEGA [1/0834/12]
- EU [ITMS: 26220220185]
- [MS SR-3634/2010-11]
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BACKGROUNDAnthocyanins, compounds that represent the major group of flavonoids in berries, are one of the most powerful natural antioxidants. The aim of this study was to evaluate biological activities and comparison of anthocyanin-rich extracts prepared from chokeberry (Aronia melanocarpa), elderberry (Sambucus nigra), bilberry (Vaccinium myrtillus) and blueberry (V. corymbosum) on the porcine intestinal epithelial IPEC-1 cell line. RESULTSThe IC50 values calculated in the antioxidant cell-based dichlorofluorescein assay (DCF assay) were 1.129 mg L-1 for chokeberry, 1.081 mg L-1 for elderberry, 2.561 mg L-1 for bilberry and 2.965 mg L-1 for blueberry, respectively. We found a significant negative correlation (P < 0.001) between cyanidin glycosides content and IC50 values. Moreover, extracts rich in cyanidin glycosides stimulated proliferation of IPEC-1 cells and did not have cytotoxic effect on cells at an equivalent in vivo concentration. CONCLUSIONSWe found that the chokeberry and elderberry extracts rich in cyanidin glycosides possess better antioxidant and anticytotoxic activities in comparison to blueberry or bilberry extracts with complex anthocyanin profiles. (c) 2015 Society of Chemical Industry
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