Journal
FOOD CHEMISTRY
Volume 141, Issue 2, Pages 1267-1272Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.foodchem.2013.04.042
Keywords
Glycaemia; Human; Insulin sensitivity; Pinitol
Funding
- University of Valencia
- Fund for Health Research (FIS) [PI12/01984, PI10/1195]
- European Regional Development Fund of the European Union (FEDER)
- Regional Ministry of Education of Valencian Community [ACOMP/2013/061]
- Valencian Regional Ministry of Health
- Carlos III Health Institute [CES10/030]
- FIS [CP10/00360]
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A limited amount of research suggests that oral ingestion of pinitol (3-O-methyl-D-chiro-inositol) positively influences glucose tolerance in humans. This study assessed the effects of different doses of pinitol supplementation on glucose tolerance, insulin sensitivity and plasma pinitol concentrations. Thirty healthy subjects underwent two one-day trials in which they consumed a nutritive beverage (Fruit Up (R)) containing 2.5, 4.0 or 6.0 g of pinitol and a corresponding placebo equivalent in both energy and carbohydrates. Blood samples were collected frequently over the 240-min test period. The pinitol-enriched beverage reduced serum glucose and insulin at 45 and 60 min, but only at a dose of 6.0 g. Plasma pinitol concentrations, maximum concentration and AUC increased according to the dose administered. The results show that a single dose of pinitol from a naturally-occurring food ingredient at the highest dose administered acutely influences indices of whole-body glucose tolerance and insulin sensitivity in healthy subjects. (C) 2013 Elsevier Ltd. All rights reserved.
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