Journal
FOOD CHEMISTRY
Volume 138, Issue 1, Pages 84-89Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.foodchem.2012.10.029
Keywords
Selenium-exopolysaccharides; Antioxidation activity; Immunomodulatory activity; Lactococcus lactis subsp lactis
Funding
- Natural Science Foundation of China [30972130, 31101314, 41276121]
- State Science and Technology Ministry of the People's Republic of China [2012BAK08B01]
- Natural Science Foundation of Zhejiang Province [Z3110211]
- Ningbo Key Project Innovation and Entrepreneurship Fund [2010C92024]
- K. C. Wong Magna Fund in Ningbo University
- Natural Science Foundation of Jiangsu Province [BK2011787]
- Natural Science Fund for Colleges and Universities in Jiangsu Province [10KJB550003]
- High Level Talents Fund of Nanjing Normal University
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Exopolysaccharide (EPS) was isolated and purified from Lactococcus lactis subsp. Lactis culture broth. Selenium chloride oxide (SeCl2O) was added to the EPS to synthesize selenium-exopolysaccharide (Se-EPS). The in vitro and in vivo antioxidant and in vivo immunomodulatory activity of EPS and Se-EPS were compared. EPS and Se-EPS scavenged superoxide anions and hydroxyl radicals. They also increased catalase (CAT), superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) activity, while decreasing malondialdehyde (MDA) levels in serum and in the livers of mice. Se-EPS showed stronger in vitro and in vivo antioxidant activity than were shown by EPS. The in vivo immunoenhancement activity of EPS and Se-EPS induced by cyclophosphamide (CY) treatment in immunosuppressed mice was researched. EPS and Se-EPS treatments increased macrophage phagocytosis, spleen and thymus indices and haemolytic complement activity (HC50). Se-EPS showed stronger immunomodulatory activity than did EPS. (C) 2012 Elsevier Ltd. All rights reserved.
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