Journal
FOOD CHEMISTRY
Volume 136, Issue 1, Pages 170-177Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.foodchem.2012.07.124
Keywords
Ginger; Zingerone; Inflammatory bowel diseases; Nuclear factor-kappa B; Interleukin-1 beta
Funding
- National Science Council
- Committee on Chinese Medicine and Pharmacy at Department of Health [CCMP100-RD-048, CCMP101-RD-103]
- China Medical University [CMU100-S-16, CMU100-S-34, CMU100-TS-14]
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Ginger is a commonly used spice with anti-inflammatory potential. Colitis is the common pathological lesion of inflammatory bowel diseases. In this study, we investigated the therapeutic effects of ginger and its component zingerone in mice with 2,4,6-trinitrobenzene sulphonic acid (TNBS)-induced colitis. Ginger and zingerone ameliorated TNBS-induced colonic injury in a dose-dependent manner. Pathway analysis of ginger- and zingerone-regulated gene expression profiles showed that ginger and zingerone significantly regulated cytokine-related pathways. Network analysis showed that nuclear factor-kappa B (NF-kappa B) and interleukin-1 beta (IL-1 beta) were key molecules involved in the expression of ginger- and zingerone-affected genes. Ex vivo imaging and immunohistochemical staining further verified that ginger and zingerone suppressed TNBS-induced NF-kappa B activation and IL-1 beta protein level in the colon. In conclusion, ginger improved TNBS-induced colitis via modulation of NF-kappa B activity and IL-1 beta signalling pathway. Moreover, zingerone might be the active component of ginger responsible for the amelioration of colitis induced by TNBS. (C) 2012 Elsevier Ltd. All rights reserved.
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