Journal
FOOD CHEMISTRY
Volume 136, Issue 2, Pages 485-490Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.foodchem.2012.09.031
Keywords
Trehalose; Toxicological effect; Forty-day study feeding study; Mutagenicity test
Funding
- Key Projects in the National Science & Technology Pillar Program during the Twelfth Five-Year Plan Period [2012BAD33803]
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In the present study, aberration, body weight, food consumption, haematology, organ coefficients, and both gross and microscopic appearance of some histiocytes were compared between the test and control groups. A sperm abnormality test, bone marrow cell micronucleus test, and a haematology study were conducted at levels of 1.25 g/kg, 2.5 g/kg, and 5 g/kg of trehalose. In both the sperm abnormality test and bone marrow cell micronucleus test, statistically significant differences were observed between the positive control and treatment groups (P < 0.05), while no statistical difference was observed among the negative control, high dose, moderate dose and low dose groups (P > 0.05). In the haematology study, there was no significant difference found from the controls at P > 0.05. The results obtained in the present study could support the conclusion that consumption of trehalose has no adverse effects for humans. (c) 2012 Elsevier Ltd. All rights reserved.
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