Journal
FOOD CHEMISTRY
Volume 138, Issue 4, Pages 2099-2107Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.foodchem.2012.11.139
Keywords
Dietary flavonoid; Kaempferol; Angiogenesis; Apoptosis; Signal transduction; Metastasis; Nanotechnology
Funding
- West Virginia Experimental Program to Stimulate Competitive Research grant
- NIH [5P2ORR016477, 8P2OGM104434]
- National Center for Research Resources
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Kaempferol is a polyphenol antioxidant found in fruits and vegetables. Many studies have described the beneficial effects of dietary kaempferol in reducing the risk of chronic diseases, especially cancer. Epidemiological studies have shown an inverse relationship between kaempferol intake and cancer. Kaempferol may help by augmenting the body's antioxidant defence against free radicals, which promote the development of cancer. At the molecular level, kaempferol has been reported to modulate a number of key elements in cellular signal transduction pathways linked to apoptosis, angiogenesis, inflammation, and metastasis. Significantly, kaempferol inhibits cancer cell growth and angiogenesis and induces cancer cell apoptosis, but on the other hand, kaempferol appears to preserve normal cell viability, in some cases exerting a protective effect. The aim of this review is to synthesize information concerning the extraction of kaempferol, as well as to provide insights into the molecular basis of its potential chemo-preventative activities, with an emphasis on its ability to control intracellular signaling cascades that regulate the aforementioned processes. Chemoprevention using nanotechnology to improve the bioavailability of kaempferol is also discussed. (C) 2012 Elsevier Ltd. All rights reserved.
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