4.6 Article

Sequential selection procedures and false discovery rate control

Publisher

WILEY-BLACKWELL
DOI: 10.1111/rssb.12122

Keywords

False discovery rate; Multiple-hypothesis testing; Sequential testing; Stopping rule

Funding

  1. National Science Foundation Graduate Research Fellowship
  2. B. C. and E. J. Eaves Stanford Graduate Fellowship
  3. Natural Sciences and Engineering Research Council of Canada Postgraduate Scholarship-Doctoral Fellowship
  4. National Science Foundation [DMS-9971405]
  5. National Institutes of Health [N01-HV-28183]

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We consider a multiple-hypothesis testing setting where the hypotheses are ordered and one is only permitted to reject an initial contiguous block H1,...,Hk of hypotheses. A rejection rule in this setting amounts to a procedure for choosing the stopping point k. This setting is inspired by the sequential nature of many model selection problems, where choosing a stopping point or a model is equivalent to rejecting all hypotheses up to that point and none thereafter. We propose two new testing procedures and prove that they control the false discovery rate in the ordered testing setting. We also show how the methods can be applied to model selection by using recent results on p-values in sequential model selection settings.

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