Preventive effect of sesame seed cake on hyperglycemia and obesity against high fructose-diet induced Type 2 diabetes in rats

The present study investigates the hypoglycemic and antiobesity effect of sesame seed cake (SSC) on rats fed with high fructose diet (HFD). SSC contained dietary fibre, lignans and phenolic compound. One month of HFD feeding induced significantly the obesity, hyperglycemia, hyperlipidaemia, insulin insensitivity and increased atherogenic index (AI). Treatment of SSC along with feed material decreased the weight gain, normalised the blood glucose (BG) level, reduced the serum cholesterol and improved the glucose tolerance significantly. In the oral glucose tolerance test (OGTT), rats fed with HFD supplemented with 2% and 4% SSC significantly reduced the plasma glucose after 120 min of glucose loading, indicating an improved glucose tolerance. In conclusion, the intake of SSC supplementation can be adopted as a therapeutic strategy for the prevention of obesity induced Type 2 hyperglycemia. (C) 2012 Elsevier Ltd. All rights reserved.