Journal
FOOD CHEMISTRY
Volume 129, Issue 3, Pages 1066-1071Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.foodchem.2011.05.076
Keywords
Oat beta-glucan; Type 2 diabetes mellitus; Hypoglycaemic effects; Intestinal disaccharidase
Funding
- Ministry of Agriculture of China [nycytx-14]
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Most physiological studies on oat beta (beta)-glucan referred to attenuation of blood glucose and insulin responses in both healthy and diabetic individuals. The main purpose of this work was to evaluate the effects of oat beta-glucan on glucose metabolism in streptozotocin-induced diabetic mice and the activities of intestinal disaccharidases in the diabetic mice and in vitro. Meanwhile, the potentially regulative mechanisms on intestinal disaccharidases were discussed. Normal and diabetic mice, treated with metformin, were used as the negative and positive controls, respectively. The results indicated that oat beta-glucan could regulate the glucose metabolism and inhibit the activities of intestinal disaccharidases in vivo and in vitro (p < 0.01), especially when using a high-dose, which suggested that oat beta-glucan could effectively improve the internal environment of intestinal tract and would be a potential alpha (alpha)-glycosidase inhibitor. (C) 2011 Elsevier Ltd. All rights reserved.
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