Journal
FOOD CHEMISTRY
Volume 125, Issue 2, Pages 483-487Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.foodchem.2010.09.037
Keywords
Wild edible vegetable; HepG2; Apoptosis; Antioxidant; p53; p21
Funding
- Rural Development Administration Republic of Korea [200901AFT1437 82462]
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The aim of this study was to investigate the biological activities, such as antioxidant and anticancer activities, of Korean wild edible vegetables. The total polyphenol content of Glehnia littoralis (Gle), Prunella vulgaris var. lilacina (Pru), Petasites japonicas (Pet), Isodon japonicas (Iso), and Tetragonia tetragonoides (Tet) extracts were 35, 193, 85, 100, and 31 mg/g, respectively. In the alpha,alpha-diphenyl-beta-picrylhydrazyl (DPPH) radical scavenging assay, Pru, Pet, and Iso extracts showed 45%, 24%, and 19% antioxidant activity, respectively. Moreover, Pru extracts also showed the highest ferric-reducing antioxidant power (FRAP) value (170 mM). In HepG2 cells, Tet and Pru extracts showed 39% and 28% anticancer activity, respectively. Assessment of apoptotic cell death in HepG2 cells showed that, compared to the control, p53, p21, and Bax expression levels increased in the presence of the extracts, while Bcl-2 expression was downregulated. (C) 2010 Elsevier Ltd All rights reserved.
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