Journal
FOOD CHEMISTRY
Volume 122, Issue 3, Pages 831-835Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.foodchem.2010.03.071
Keywords
Rabdosia rubescens (Hemsl.); Flavonoids, human cancer cell lines (Hep G2, COLO 205, MCF-7, and HL-60); Anti-inflammatory
Ask authors/readers for more resources
Eight flavonoids, 5,8,4'-trihydroxy-6,7,3'-trimethoxyflavone (1), 5,4'-dihydroxy-6,7,8,3'-tetramethoxyflavone (2), nodifloretin (3), pedalitin, (4), penduletin (5), cirsiliol (5), luteolin (7), and quercetin (8), were isolated from the aerial parts of Rabdosia rubescens. Structures were established on the basis of 1D and 2D NMR and HRMS data. All flavonoids were tested for cytotoxicity in a small panel of cancer cell lines (Hep G2, COLD 205, MCF-7, and HL-60) and anti-inflammatory activity in LPS-treated RAW264.7 macrophage. Among them, compounds (1) and (4) were modestly active for inhibiting nitrite production in macrophage. Compound (2) was demonstrated to be selectively active against HL-60 cells with an IC50 of 7.55 mu M. This value is comparable to the IC50 4.64 mu M of doxorubicin, the positive control used in this investigation. (C) 2010 Elsevier Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available