Journal
FOOD CHEMISTRY
Volume 118, Issue 3, Pages 686-692Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.foodchem.2009.05.034
Keywords
Antioxidant activity; Anti-inflammatory activity; Antinociceptive activity; Aldose reductase inhibitory activity; Sideritis brevibracteata; Lamiaceae
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The Sideritis species are widely used in the treatment of gastrointestinal disorders, rheumatism, cough, the common cold and as a diuretic, and they are commonly used as an herbal tea in folk medicine in Turkey. The teas of Sideritis have unique tastes, pleasant aromas and a transparent yellow colour, and are preferred as a hot beverage. In order to evaluate this information, the crude methanolic extract and the water soluble part of the methanolic extract after partition with chloroform and n-butanol were investigated for their anti-inflammatory and antinociceptive activities. Phytochemical studies performed on the n-butanol extract of the overground parts of Sidentis brevibracteata, which is rich in phenolic compounds with promising activities, resulted in the isolation of six acetylated allose containing 8-hydroxyflavone glycosides and a phenylethanoid glycoside. The structures of the compounds were established by spectroscopic evidence (UV, IR, NMR, MS). Furthermore, these phenolic compounds of S. brevibracteato were studied for anti-inflammatory, anti nociceptive, antioxidant and aldose reductase inhibitory activities. The experimental data demonstrated that S. brevibracteata displayed remarkable anti-inflammatory, antinociceptive and antioxidant activities. (C) 2009 Elsevier Ltd. All rights reserved.
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