A new phragmalin-type limonoid and anti-inflammatory constituents from the fruits of Swietenia macrophylla

The fruit of Swietenia macrophylla is commercially used in healthcare products for the improvement of blood circulation and skin condition. A new phragmalin-type limonoid, 6-0-acety1-3'-demethylswietephragmin E (1), has been isolated from the fruit of S. macrophylla, together with 16 known compounds. The structure of this new compound was determined through spectroscopic and MS analyses. 6-O-Acetyl-3'-demethylswietephragmin E (1), 3,6-O,O-diacetylswietenolide (5), 3-O-tigloylswietenolide (6). 3-O-tigloyl-6-O-acetylswietenolide (8), swietemahonin E (9), and 6-O-acetylswietemahonin G (10) exhibited inhibition (IC(50) <= 35.7 mu M) Of Superoxide anion generation by human neutrophils in response to formyl-L-methionyl-L-leucyl-L-phenylaianine (fMLP). (C) 2009 Elsevier Ltd. All rights reserved.