Journal
FOOD CHEMISTRY
Volume 119, Issue 3, Pages 896-902Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.foodchem.2009.07.056
Keywords
Lignan glycoside; Sesame meal; Transport; Absorption; Nanotechnology; Caco-2 cell monolayer
Funding
- Department of Health, Taiwan [DOH97-TD-F-113]
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In the present study, we investigated whether lignan glycosides from sesame meal (LGSM), after nano/sub-microsizing, will exhibit higher transport and absorption efficiencies than LGSM. The average particle size of 1% LGSM aqueous suspension reduced from approximately 2 mu m-200 nm after media-milling with zirconia beads. The transport and absorption of LGSM and nano/sub-microsized LGSM (N-LGSM) using Caco-2 human epithelial colorectal adenocarcinoma cells, a model simulating human intestinal absorption was examined. The permeability of sesaminol triglucoside (ST) in N-LGSM and LGSM was 1.41 +/- 0.16 and 1.07 +/- 0.21 (10(-6) cm/s), respectively, indicating that ST in N-LGSM was more efficiently transported through the monolayer. In addition, N-LGSM exhibited 35.7% higher absorption efficiency than LGSM. The better performance of N-LGSM may be attributed to the (a) smaller particle size and larger surface area: (b) increased mucosal permeability, and (c) improved intestinal absorption due to the formation of nanoemulsion droplets. (C) 2009 Elsevier Ltd. All rights reserved.
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