Journal
FOOD CHEMISTRY
Volume 115, Issue 2, Pages 412-418Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.foodchem.2008.12.020
Keywords
Elaeocarpus sylvestris var. ellipticus; Antioxidant; 1,2,3,4,6-Penta-O-galloyl-beta-D-glucose (PGG); Antioxidant enzyme
Funding
- Ministry of Science & Technology of Korea (KOSEF) [M1063901]
- National Research Council of Science & Technology (NST), Republic of Korea [K09190] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
- National Research Foundation of Korea [2005-04730, 핵06A3304, 2006-2002296, 2005-04728] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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The antioxidant potential of 1,2,3,4,6-penta-O-galloyl-beta-D-glucose (PGG), isolated from Elaeocarpus sylvestris var. ellipticus, was investigated by various established systems based on cell-free and cell system experiments, such as radical detection, antioxidant enzyme assay, lipid peroxidation detection, and cell viability assay. PGG was found to quench the 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical and intracellular reactive oxygen species. PGG recovered the cellular antioxidant enzyme activities of superoxide dismutase, catalase, and glutathione peroxidase, which were reduced by H2O2 treatment, thereby resulting in the inhibition of lipid peroxidation. Cytoprotective effects of PGG were based on the results of DNA fragmentation, mitochondrial membrane potential (Delta psi), apoptotic body formation, and caspase-3 activity. The results suggest that PGG protects cells against H2O2-induced cell damage via antioxidant properties. (C) 2008 Elsevier Ltd. All rights reserved.
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