Journal
FOOD CHEMISTRY
Volume 114, Issue 4, Pages 1316-1320Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.foodchem.2008.11.009
Keywords
Asteraceae; Scorzonera austriaca; Dimeric sesquiterpenoid; Cytotoxicity
Funding
- National Basic Research Program of China [2007CB108903]
- Natural Science Foundation of Gansu Province [ZS001-A25-002-Z]
- National Science Foundation of China (NSFC) [J0630962/J0109]
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The root of Scorzonera austriaca has been used in indigenous cuisines as a delicious food and in the Tibetan traditional medicine in northwestern China. Two novel dimeric guaianolides linked by a carbon-carbon bond with a rare carbon skeleton, termed biguaiascorzolides A (1) and B (2), respectively, have been isolated from roots of S. austriaca. Acetylation of 1 gave 1 a. The structures of 1, 1 a and 2 were characterised by HR-ESI-MS, EI-MS, UV, IR, and 1D- and 2D-NMR techniques ((1)H and (13)C NMR, (1)H-(1)H COSY, HMQC, HMBC, and NOESY experiments). The cytotoxicity of la was assayed against selected cancer cell lines, including the human erythroleukaemia adriamycin-resistant subline (K562/ADM) and human stomach carcinoma (MGC-803) cell lines. Compound la exhibits a moderate activity against K562/ADM cell lines (IC(50) 39.8 mu m) and is inactive towards MCC-803 cell lines. (C) 2008 Elsevier Ltd. All rights reserved.
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