Journal
FOOD CHEMISTRY
Volume 106, Issue 2, Pages 529-535Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.foodchem.2007.06.037
Keywords
Broussonetia papyrifera; flavonol; chalcone; tyrosinase inhibition
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Fractionation of a chloroform-soluble extract from twigs of Broussonetia papyrifera, led to the isolation of one new compound, 3,5,7,4'-tetrahydroxy-3'-(2-hydroxy-3-methylbut-3-enyl)flavone (1), and 10 known compounds, uralenol (2), quercetin (3), isolicoflavonol (4), papyriflavonol A (5), broussoflavonol F (6), 5,7,3',5'-tetrahydroxyflavanone (7), luteolin (8), isoliquiritigenin (9), broussochalcone A (10) and 5,7,3',4'-tetrahydroxy-3-methoxyflavone (11). Their structures were identified by interpretation of MS, H-1 NMR, C-13 NMR, HMQC and HMBC data. Their inhibitory activities on mushroom tyrosinase using L-tyrosine as substrate were investigated and the IC50 values of 3,5,7,4'-tetrahydroxy-3'-(2-hydroxy-3-methylbut-3-enyl)flavone, uralenol, quercetin and broussoflavonol F were found to be 96.6, 49.5, 57.8, and 82.3 mu M, respectively, better than arbutin, a well-known tyrosinase inhibitor. (C) 2007 Elsevier Ltd. All rights reserved.
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