Journal
JOURNAL OF THE ROYAL SOCIETY INTERFACE
Volume 12, Issue 111, Pages -Publisher
ROYAL SOC
DOI: 10.1098/rsif.2015.0779
Keywords
mesoporous magnesium-calcium silicate; calcium sulfate; bone cement; degradability; cytocompatibility
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Funding
- National Natural Science Foundation of China [51173041, 31271031]
- National Science and Technology Support Plan Projects [2012BAD32B01]
- International Cooperation Project of the Ministry of Science and Technology of China [2013DFB50280]
- Major International Joint Research Project between China and Korea [81461148033, 31311140253]
- Key Medical Program of Science and Technology Development of Shanghai [12441902802]
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Mesoporous calcium sulfate-based bone cements (m-CSBC) were prepared by introducing mesoporous magnesium-calcium silicate (m-MCS) with specific surface area (410.9 m(2) g(-1)) and pore volume (0.8 cm(3) g(-1)) into calcium sulfate hemihydrate (CSH). The setting time of the m-CSBC was longer with the increase of m-MCS content while compressive strength decreased. The degradation ratio of m-CSBC increased from 48.6 w% to 63.5 w% with an increase of m-MCS content after soaking in Tris-HCl solution for 84 days. Moreover, the m-CSBC containing m-MCS showed the ability to neutralize the acidic degradation products of calcium sulfate and prevent the pH from dropping. The apatite could be induced on m-CSBC surfaces after soaking in SBF for 7 days, indicating good bioactivity. The effects of the m-CSBC on vitamin D-3 sustained release behaviours were investigated. It was found that the cumulative release ratio of vitamin D-3 from the m-CSBC significantly increased with the increase of m-MCS content after soaking in PBS (pH = 7.4) for 25 days. The m-CSBC markedly improved the cell-positive responses, including the attachment, proliferation and differentiation of MC3T3-E1 cells, suggesting good cytocompatibility. Briefly, m-CSBC with good bioactivity, degradability and cytocompatibility might be an excellent biocement for bone regeneration.
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