Journal
FOOD CHEMISTRY
Volume 107, Issue 2, Pages 813-819Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.foodchem.2007.08.086
Keywords
Syzygium samarangense; chalcones; flavonoids; cytotoxic activity; antioxidants
Funding
- NIGMS NIH HHS [S06 GM008225-18, S06 GM008225] Funding Source: Medline
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Bioassay-guided fractionation of the methanolic extracts of the pulp and seeds of the fruits of Syzygium samarangense (Blume) Merr. and L.M. Perry led to the identification of four cytotoxic compounds and eight antioxidants on the basis of HPLC-PDA analysis, MS, and various NMR spectroscopic techniques. Three C-methylated chalcones, 2',4'-dihydroxy-3',5'-dimethyl-6'-methoxychalcone (1), 2',4'-dihydroxy-3'-methyl-6'-methoxychalcone (stercurensin, 2), and 2',4'-dihydroxy-6'-methoxychalcone (cardamonin, 3), were isolated and displayed cytotoxic activity (IC50 = 10, 35, and 35 mu M, respectively) against the SW-480 human colon cancer cell line. Also a number of known antioxidants were obtained including six quercetin glycosides: reynoutrin (4), hyperin (5), myricitrin (6), quercitrin (7), quercetin (9), and guaijaverin (10), one flavanone: (S)-pinocembrin (8), and two phenolic acids: gallic acid (11) and ellagic acid (12). (C) 2007 Elsevier Ltd. All rights reserved.
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